DSR 6434, CAS 1059070-10-8

Formulation: A solid

Formal Name: 6-amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-8H-purin-8-one

Purity: ≥98%

Formula Markup: C19H28N8O2

Formula Weight: 400,5

Shelf life (days): 1460

CAS Number: 1059070-10-8

Notes: DSR 6434 is an agonist of toll-like receptor 7 (TLR7).{58622} It induces reporter gene activity in HEK293 cells expressing human TLR7 (EC50 = 7.9 nM) but not HEK293 cells expressing human TLR8 or TLR9. DSR 6434 (0.64-2,000 nM) induces production of chemokine (C-X-C motif) ligand 10 (CXCL10), IL-12p70, IFN-γ, and TNF-α in splenocytes isolated from Tlr7 wild-type, but not Tlr7-/-, mice. In vivo, DSR 6434 (0.1 mg/kg) reduces tumor volume and increases survival, as well as potentiates the antitumor effects of ionizing radiation, in a CT26 murine colon cancer model. It also potentiates the antitumor effects of ionizing radiation and decreases the number of metastases in a KHT murine fibrosarcoma model.

• Artikelnummer: CAY34331-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34331-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK