(E/Z)-4-hydroxy Tamoxifen-d5, CAS 2470232-57-4

Formulation: A solid

Formal Name: 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl-3,3,4,4,4-d5]-phenol

Purity: ≥99% deuterated forms (d1-d5)

Formula Markup: C26H24D5NO2

Formula Weight: 392,6

Shelf life (days): 1460

CAS Number: 2470232-57-4

Notes: (E/Z)-4-hydroxy Tamoxifen-d5 is intended for use as an internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen (Item No. 17308) by GC- or LC-MS. (E/Z)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen (Item No. 13258).{28446} It is formed from tamoxifen by the cytochrome P450 (CYP) isoform CYP2D6. (E/Z)-4-hydroxy Tamoxifen is cytotoxic to MCF-7 and MDA-MB-231 breast cancer cells (IC50s = 27 and 18 µM, respectively).{28444} It also stimulates LC3 lipidation and the formation of autophagic vesicles in MCF-7 cells in a superoxide-dependent manner.{28445}

• Artikelnummer: CAY34232-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34232-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung