EG 00229 (trifluoroacetate salt), CAS 1210945-69-9

Formulation: A solid

Formal Name: N2-[[3-[(2,1,3-benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine, 2,2,2-trifluoroacetate

Purity: ≥98%

Formula Markup: C17H19N7O5S3 • CF3COOH

Formula Weight: 611,6

Shelf life (days): 1460

CAS Number: 1210945-69-9

Notes: EG 00229 is an antagonist of neuropilin-1 (NRP-1).{54952} It inhibits the binding of VEGF-A to porcine aortic endothelial cells expressing NRP-1, but not VEGFR2, with an IC50 value of 8 µM. EG 00229 (100 µM) reduces VEGF-A-induced migration of human umbilical vein endothelial cells (HUVECs) and enhances the cytotoxicity of paclitaxel (Item No. 10461) or 5-fluorouracil (Item No. 14416) in A549 lung cancer cells. It also reduces severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectivity in Caco-2 cells when used at a concentration of 100 µM.{54953}

• Artikelnummer: CAY33937-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33937-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK