rac-Eletriptan-d3 (hydrobromide)

Formulation: A solid

Formal Name: 3-((1-(methyl-d3)pyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)ethyl)-1H-indole, monohydrobromide

Purity: ≥99% deuterated forms (d1-d3)

Formula Markup: C22H23D3N2O2S • HBr

Formula Weight: 466,5

Shelf life (days): 1460

Notes: rac-Eletriptan-d3 is intended for use as an internal standard for the quantification of eletriptan (Item No. 20048) by GC- or LC-MS. Eletriptan is an agonist of the serotonin (5-HT) receptor types 5-HT1B and 5-HT1D.{32188} It inhibits forskolin-induced cAMP accumulation in and induces vasoconstriction of isolated rabbit common carotid artery rings (pD2s = 7.6 and 4.9, respectively), an effect that can be blocked by the 5-HT1B antagonist SB216641 but not the 5-HT1D antagonist BRL15572. Eletriptan preferentially induces constriction of isolated human cerebral over coronary arteries (EC50s = 15.8 and 1,995 nM, respectively).{42283} Formulations containing eletriptan have been used in the treatment of migraine headache.

• Artikelnummer: CAY25418-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25418-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung