EM574, CAS 110480-13-2

Formulation: A solid

Formal Name: 8,9-didehydro-N-demethyl-9-deoxo-6-deoxy-6,9-epoxy-N-(1-methylethyl)-erythromycin

Purity: ≥98%

Formula Markup: C39H69NO12

Formula Weight: 744

Shelf life (days): 1460

CAS Number: 110480-13-2

Notes: EM574 is a motilin receptor agonist with an IC50 value of 6.17 nM for binding to rabbit gastric antral smooth muscle homogenates in a radioligand binding assay.{45198} It also binds to human smooth muscle homogenates in a radioligand binding assay (Kd = 7.8 nM).{45199} EM574 induces contraction of isolated rabbit, but not rat or guinea pig, intestine (EC50 = 5.5 nM).{45198} It increases antral motility and enhances gastric emptying in canine models of gastroparesis when administered intraduodenally at a dose of 0.03 mg/kg following a semi-solid meal.{45200}

• Artikelnummer: CAY27752-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27752-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK