Endothelin-3 (human, rat) (trifluoroacetate salt)

Formulation: A lyophilized powder

Formal Name: L-cysteinyl-L-threonyl-L-cysteinyl-L-phenylalanyl-L-threonyl-L-tyrosyl-L-lysyl-L-α-aspartyl-L-lysyl-L-α-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-tyrosyl-L-cysteinyl-L-histidyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophan cyclic (1→15),(3→11)-bis(disulfide), 2,2,2-trifluoroacetate

Purity: ≥95%

Formula Markup: C121H168N26O33S4 • XCF3COOH

Formula Weight: 2643

Shelf life (days): 1460

Notes: Endothelin-3 is a peptide vasoconstricter and a ligand of the endothelin (ET) receptors ETA and ETB (Kbs = 1.05 and 1.49, respectively).{39489} It induces β-arrestin recruitment in CHO-K1 cells expressing human ETA and ETB (pD2s = 7.31 and 9.44, respectively). Endothelin-3 increases blood pressure in spontaneously hypertensive and normotensive rats when administered at doses of 310 and 955 pmol/kg, respectively.{39490} It also stimulates migration and adhesion of enteric neural crest cells (ENCCs) to the embryonic gut in mice via interaction with ETB.{39491} Mutations in the endothelin-3 gene, Edn3, induce distal aganglionosis caused by failed colonization of ENCCs in the hindgut and lack of ENCC migration to the ileo-caecal junction in mice.

• Artikelnummer: CAY24413-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24413-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK