(±)-Epibatidine (hydrochloride), CAS 162885-01-0

Formulation: A solid

Formal Name: (1R,2R,4S)-rel-2-(6-chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane, dihydrochloride

Purity: ≥98%

Formula Markup: C11H13ClN2 • 2HCl

Formula Weight: 281,6

Shelf life (days): 1460

CAS Number: 162885-01-0

Notes: (±)-Epibatidine is an alkaloid that has been found in Ecuadoran poison frog (E. tricolor) skin extracts and an agonist of α4β2 subunit-containing nicotinic acetylcholine receptors (nAChRs; Ki = 43 pM).{52706,52707} It is selective for α4β2 subunit-containing nAChRs over α7 nAChRs (Ki = 230 nM).{52706} (±)-Epibatidine enhances 86Rb+ flux in IMR-32 cells (EC50 = 7 nM) and induces dopamine release from rat striatal slices (EC50 = 0.4 nM), effects that can be reduced by the nAChR antagonist mecamylamine (Item No. 14602). In vivo, (±)-epibatidine induces analgesia in the hot plate test and the Straub-tail response in mice (ED50s = 0.005 and 0.02 mg/kg, respectively).{52707}

• Artikelnummer: CAY31193-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 31193-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK