ERB 041, CAS 524684-52-4

Formulation: A crystalline solid

Formal Name: 7-ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol

Purity: ≥95%

Formula Markup: C15H10FNO3

Formula Weight: 271,2

Shelf life (days): 1460

CAS Number: 524684-52-4

Notes: ERB 041 is an estrogen receptor β (ERβ) agonist (IC50s = 5.4, 3.1, and 3.7 nM for the human, rat, and mouse receptors, respectively).{53106} It is selective for ERβ over ERα (IC50s = 1,200, 620, and 750 nM for human, rat, and mouse ERα, respectively). ERB 041 induces IGFBP4 mRNA expression in Saos-2 cells expressing human ERβ (EC50 = 20 nM). In vivo, ERB 041 (0.1 and 0.3 mg/kg) inhibits chronic diarrhea and reduces colonic ulceration, inflammation, and fibrosis in the HLA-B27 transgenic rat model of inflammatory bowel disease. It reduces joint swelling in a rat model of adjuvant-induced arthritis when administered at a dose of 1 mg/kg. ERB 041 (10 mg/kg) also reduces lesion formation in a mouse model of endometriosis.{53107}

• Artikelnummer: CAY28737-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28737-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK