Erteberel, CAS 533884-09-2

Formulation: A crystalline solid

Formal Name: (3aS,4R,9bR)-1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-cyclopenta[c][1]benzopyran-8-ol

Purity: ≥98%

Formula Markup: C18H18O3

Formula Weight: 282,3

Shelf life (days): 1460

CAS Number: 533884-09-2

Notes: Erteberel is an estrogen receptor beta (ERβ) agonist.{37486} It is selective for ERβ over ERα in reporter assays using PC3 cells expressing the human receptors (EC50s = 0.66 and 19.4 nM, respectively). Ertebrel (5 µM) induces apoptosis and cell cycle arrest at the G2/M phase in U87MG and U251 glioblastoma cells.{34787} It enhances cytotoxicity induced by cisplatin (Item No. 13119), lomustine (Item No. 21237), or bleomycin (Item No. 13877) in U251 cells when used at a concentration of 1 µM. Ertebrel (5 mg/kg) reduces tumor growth in a U251 orthotopic model of glioblastoma in ovariectomized mice. It decreases prostate weight but does not affect serum testosterone or dihydrotestosterone levels in a mouse model of benign prostatic hyperplasia (BPH) when administered at doses of 0.01, 0.025, and 0.05 mg/kg.{34786}

• Artikelnummer: CAY22130-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22130-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK