Eslicarbazepine Acetate, CAS 236395-14-5

Formulation: A solid

Formal Name: (10S)-10-(acetyloxy)-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide

Purity: ≥95%

Formula Markup: C17H16N2O3

Formula Weight: 296,3

Shelf life (days): 1460

CAS Number: 236395-14-5

Notes: Eslicarbazepine acetate is a sodium channel blocker (IC50 = 138 nM in a radioligand binding assay).{40363} It inhibits sodium uptake in a dose-dependent manner in rat cortical synaptosomes at concentrations ranging from 30-300 μM. In vivo, oral and i.p. administration of eslicarbazepine acetate is protective against seizures induced by maximal electroshock (MES) in mice with ED50 values of 4.7 and 6.3 mg/kg, respectively, which are well below the median toxic dose (TD50) values of 358.7 and 78.6 mg/kg for oral and i.p. administration respectively. High-dose administration (30 mg/kg) of eslicarbazepine acetate prevents picrotoxin-induced seizures in rats.{40364} Low-dose administration (10 mg/kg) does not suppress picrotoxin-induced seizures, however, it reduces seizure number and duration. Formulations containing eslicarbazepine acetate have been used for the treatment of partial-onset seizures.{40365}

• Artikelnummer: CAY23656-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23656-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK