Eticlopride (hydrochloride), CAS 97612-24-3

Formulation: A crystalline solid

Formal Name: 3-chloro-5-ethyl-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-6-hydroxy-2-methoxy-benzamide, monohydrochloride

Purity: ≥98%

Formula Markup: C17H25ClN2O3 • HCl

Formula Weight: 377,3

Shelf life (days): 1460

CAS Number: 97612-24-3

Notes: Eticlopride is a dopamine D2 and D3 receptor antagonist (Kis = 0.029 and 0.46 nM in MN9D mouse neuronal cells expressing rat D2 and human D3 receptors, respectively).{45603} It is selective for dopamine D2 and D3 receptors (IC50s = 1 and 113 nM, respectively) over dopamine D1, α2-adrenergic, and β-adrenergic, histamine H1, and muscarinic receptors (IC50s = 700->100,000 nM), as well as the serotonin (5-HT) receptor subtypes 5-HT1 and 5-HT2 (IC50s = 6,200 and 830, respectively), but does bind α1-adrenergic receptors (α1-ARs; IC50 = 110 nM) in radioligand binding assays.{45604} Eticlopride (10 μg/kg) inhibits stereotyped behavior in rats induced by 7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT).{45605} It also inhibits ketamine- and cocaine-induced hypermotility in rats when administered at doses of 20 and 50 μg/kg, respectively.

• Artikelnummer: CAY29112-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29112-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK