Etifoxine-13C-d3, CAS 2738376-67-3

Formulation: A solid

Formal Name: 6-chloro-N-ethyl-4-methyl-13C-d3-4-phenyl-4H-3,1-benzoxazin-2-amine

Purity: ≥99% deuterated forms (d1-d3)

Formula Markup: C16[13C]H14D3ClN2O

Formula Weight: 304,8

Shelf life (days): 1460

CAS Number: 2738376-67-3

Notes: Etifoxine-13C-d3 is intended for use as an internal standard for the quantification of etifoxine (Item No. 15999) by GC- or LC-MS. Etifoxine is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors.{26117} It selectively increases GABA-induced currents in X. laevis oocytes expressing α1β2γ2 or α1β3γ2 over α1β1γ2 subunit-containing receptors at 20 µM. Etifoxine inhibits binding of the GABAA receptor agonist muscimol in rat corticol membranes with a Kd value of 23 nM in a radioligand binding assay.{53410} It increases NGF-induced neurite outgrowth in PC12 cells when used at a concentration of 20 µM.{26118} Etifoxine (12.5 mg/kg, i.p.) increases the percentage of time spent in the open arms of the elevated plus maze in high-anxiety BALB/cByJ, but not C57BL/6, mice, indicating anxiolytic-like activity.{53411} It increases the seizure threshold in a mouse model of seizures induced by picrotoxin (Item No. 20771) with a minimum effective dose (MED) of 75 mg/kg.{53410} Etifoxine (50 mg/kg, i.p.) also increases the paw withdrawal threshold on the ipsilateral side in a rat model of rheumatoid arthritis induced by complete Freund's adjuvant.{53412}

• Artikelnummer: CAY30235-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30235-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung