Etiocholanolone, CAS 53-42-9

Formulation: A solid

Formal Name: (5β)-3α-hydroxy-androstan-17-one

Purity: ≥98%

Formula Markup: C19H30O2

Formula Weight: 290,4

Shelf life (days): 1460

CAS Number: 53-42-9

Notes: Etiocholanolone is an androgenically inactive metabolite of testosterone and androstenedione and the 5β epimer of androsterone (Item No. 15872).{57692,35430} It increases the frequency of long channel openings and potentiates GABA-induced chloride currents in HEK293 cells expressing rat α1β2γ2L subunit-containing GABAA receptors when used at a concentration of 10 µM.{57693} Etiocholanolone is protective against seizures induced by 6 Hz electroshock or pentylenetetrazol (PTZ; ED50s = 76.9 and 139 mg/kg, respectively).{57694} It is also pyretic in an IL-1-dependent manner, inducing increases in body temperature in rhesus macaques but not squirrel monkeys that lack testosterone and androstenedione metabolizing enzymes.{57695}

• Artikelnummer: CAY34501-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34501-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK