Etrasimod, CAS 1206123-37-6

Formulation: A crystalline solid

Formal Name: (3R)-7-[[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy]-1,2,3,4-tetrahydro-cyclopent[b]indole-3-acetic acid

Purity: ≥95%

Formula Markup: C26H26F3NO3

Formula Weight: 457,5

Shelf life (days): 1460

CAS Number: 1206123-37-6

Notes: Etrasimod is an orally bioavailable and potent antagonist of sphingosine-1-phosphate (S1P) receptors with EC50 values of 0.093, 0.44, 0.32, 0.34, and 0.32 nM for human, mouse, rat, dog, and monkey S1P1 receptors.{41302} It is selective for S1P1, S1P4, and S1P5 receptors with EC50 values of 6.1, >10,000, >10,000, 147, and 24.4 nM for S1P1-5, respectively, in a β-arrestin assay. Etrasimod (1 mg/kg, i.v.) decreases peripheral lymphocytes in mouse, rat, dog, and monkey (IC50s = 101, 51, 58, and 98 nM, respectively). It delays or prevents the onset and severity of murine experimental autoimmune encephalomyelitis (EAE) when administered at 0.3, 1, or 3 mg/kg. It also leads to lower EAE disease scores relative to vehicle when administered after disease onset and is efficacious in a rat model of collagen-induced arthritis.

• Artikelnummer: CAY21661-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21661-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK