EVP-6124 (hydrochloride), CAS 550999-74-1

Formulation: A crystalline solid

Formal Name: N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-7-chloro-benzo[b]thiophene-2-carboxamide, monohydrochloride

Purity: ≥95%

Formula Markup: C16H17ClN2OS • HCl

Formula Weight: 357,3

Shelf life (days): 1460

CAS Number: 550999-74-1

Notes: EVP-6124 is a partial agonist of α7 subunit-containing nicotinic acetylcholine receptors (nAChRs; IC50 = 22.38 nM).{52384} It is 1,000-fold selective for α7 subunit-containing nAChRs over α4β2 subunit-containing nAChRs at 10 µM, as well as a panel of 60 peptide and nonpeptide receptors, ion channels, and transporters. EVP-6124 induces inward currents in Xenopus oocytes expressing human α7 subunit-containing nAChRs (EC50 = 0.16 µM). In vivo, EVP-6124 (0.1, 0.3, and 1 mg/kg) reverses scopolamine-induced deficits in the novel object recognition task and prevents natural forgetting of a familiar object in rats. It reduces premature responding, a measure of impulsivity, by low-attentive but not high-attentive female rats in the 5-choice serial reaction time test (5CSRTT).{52385}

• Artikelnummer: CAY30073-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30073-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK