Falcarinol, CAS 21852-80-2

Formulation: A solution in ethanol

Formal Name: 1,9Z-heptadecadiene-4,6-diyn-3R-ol

Purity: ≥60%

Formula Markup: C17H24O

Formula Weight: 244,4

Shelf life (days): 730

CAS Number: 21852-80-2

Notes: Falcarinol is a C17-polyacetylene produced by the Apiaceae family that has antimicrobial properties due to its inhibition of fatty acid biosynthesis.{38102,38105} Falcarinol binds to the human recombinant cannabinoid (CB) receptors, CB1 and CB2, (Kis = 594 and 2,100 nM, respectively) in an [3H]anandamide displacement assay in HEK293 cells.{38104} It differentially modulates synaptic and extrasynaptic GABAA receptors in a recombinant HEK293 system.{38101} In vitro assays of ATPase activity demonstrate that falcarinol inhibits breast cancer resistance protein ATP-binding cassette sub-family G member 2 (ABCG2; IC50 = 79.3 μM), a drug efflux transporter and mediator of drug resistance.{38106} Falcarinol (6.88 μg/g feed) also inhibits aberrant crypt foci by 26.6% in azoxymethane-induced rats.{38103}

• Artikelnummer: CAY22407-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22407-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK