(±)-Felodipine-d5, CAS 1242281-38-4

Formulation: A solid

Formal Name: 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3-(ethyl-d5) 5-methyl ester

Purity: ≥99% deuterated forms (d1-d5)

Formula Markup: C18H14Cl2D5NO4

Formula Weight: 389,3

Shelf life (days): 1460

CAS Number: 1242281-38-4

Notes: (±)-Felodipine-d5 is intended for use as an internal standard for the quantification of felodipine (Item No. 17535) by GC- or LC-MS. Felodipine is an inhibitor of L-type calcium channels.{28544} It induces relaxation of precontracted isolated porcine coronary artery segments (EC50 = 0.15 nM), which highly express L-type calcium channels.{53284} Felodipine is selective for L-type calcium channels over N-, R-, and P/Q-type channels at 10 µM, as well as the T-type Cav3.2 channel (IC50 = 6.8 µM).{28544,28732} Felodipine preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 33.9 and 3,981 nM, respectively).{28545} It decreases mean arterial blood pressure and total peripheral resistance in a rabbit model of hypertension induced by renal artery ligation when administered intravenously at doses of 30 and 100 nmol/kg.{53285}

• Artikelnummer: CAY30123
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30123-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung