Fenobam (hydrate), CAS 63540-28-3

Formulation: A crystalline solid

Formal Name: N-(3-chlorophenyl)-N′-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)-urea, monohydrate

Purity: ≥98%

Formula Markup: C11H11ClN4O2 • H2O

Formula Weight: 284,7

Shelf life (days): 1460

CAS Number: 63540-28-3

Notes: Fenobam is a noncompetitive antagonist and inverse agonist of metabotropic glutamate receptor 5 (mGluR5) that binds to an allosteric site.{52400} It inhibits intracellular calcium mobilization induced by the glutamate analog quisqualate (Item No. 20211) in HEK293 cells expressing the human receptor (IC50 = 58 nM) and inhibits basal activity of mGluR5 in a cell-based assay (IC50 = 84 nM).{52400} Fenobam (10 and 30 mg/kg) reduces stress-induced hyperthermia in mice and increases drinking time in the Vogel conflict test in rats when administered at a dose of 30 mg/kg, indicating anxiolytic-like activity. It induces analgesia in the formalin test in mice when administered at a dose of 30 mg/kg.{52401}

• Artikelnummer: CAY29759-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29759-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK