Fenspiride-d5, CAS 1246911-67-0

Formulation: A solid

Formal Name: 8-(phenethyl-d5)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

Purity: ≥99% deuterated forms (d1-d5)

Formula Markup: C15H15D5N2O2

Formula Weight: 265,4

Shelf life (days): 1460

CAS Number: 1246911-67-0

Notes: Fenspiride-d5 is intended for use as an internal standard for the quantification of fenspiride (Item No. 25512) by GC- or LC-MS. Fenspiride is an antagonist of histamine H1 receptors and a non-steroidal anti-inflammatory drug (NSAID).{36842,36843} It inhibits histamine-induced contraction of isolated guinea pig trachea but not histamine-induced inotropy of isolated guinea pig heart. It also inhibits phosphodiesterase 4 (PDE4), PDE5, and PDE3 (IC50s = 69, ~158, and 363 µM, respectively, in isolated human bronchi derived from patients with lung cancer).{36844} It is selective for these phosphodiesterases over PDE1 and PDE2, where it provides less than 25% inhibition. Fenspiride potentiates the airway relaxant effects of isoproterenol (Item No. 15592) and sodium nitroprusside indicating an effect on cAMP and cGMP phosphodiesterases, respectively. Aerosolized fenspiride (1 mg/ml) reverses bronchoconstriction induced by capsaicin and, when used at aerosolized concentrations ranging from 1-10 mg/ml, reduces cough induced by citric acid in a guinea pig model of cough.{36843}

• Artikelnummer: CAY33711-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33711-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung