FIDAS-3, CAS 1266684-01-8

Formulation: A solid

Formal Name: 4-[(1E)-2-(2,6-difluorophenyl)ethenyl]-N,N-dimethyl-benzenamine

Purity: ≥98%

Formula Markup: C16H15F2N

Formula Weight: 259,3

Shelf life (days): 1460

CAS Number: 1266684-01-8

Notes: FIDAS-3 is an inhibitor of S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2; IC50 = 4.9 µM).{65612} It also is an inhibitor of human-ether-a-go-go (hERG; IC50 = 32.1 µM in a voltage-clamp assay using HEK293 cells expressing hERG).{65613} FIDAS-3 reduces the proliferation of LS 174T colorectal cancer cells (IC50 = 26.9 µM) and the levels of Axin2 and c-Myc in the same cells when used at a concentration of 10 µM.{65612,65614} Intraperitoneal administration of FIDAS-3 (20 mg/kg per day) decreases tumor growth in an LS 174T mouse xenograft model.{65614}

• Artikelnummer: CAY37716-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37716-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe