Filorexant, CAS 1088991-73-4

Formulation: A solid

Formal Name: [(2R,5R)-5-[[(5-fluoro-2-pyridinyl)oxy]methyl]-2-methyl-1-piperidinyl][5-methyl-2-(2-pyrimidinyl)phenyl]-methanone

Purity: ≥98%

Formula Markup: C24H25FN4O2

Formula Weight: 420,5

Shelf life (days): 1460

CAS Number: 1088991-73-4

Notes: Filorexant is a dual antagonist of orexin 1 receptor (OX1R) and OX2R (Kis = 2.5 and 0.31 nM, respectively, for the recombinant human receptors).{48849} It selectively inhibits OX1R and OX2R over a panel of more than 170 receptors and enzymes. Filorexant inhibits orexin A-induced calcium mobilization in CHO cells expressing recombinant human OX1R or OX2R (Kb = 11 nM for both). It decreases locomotor activity in rats during the dark cycle when administered at a dose of 10 mg/kg. Filorexant (0.5 mg/kg) reduces the time spent awake and decreases the latency to slow-wave sleep stage 1 (SWS1) and SWS2, but not rapid eye movement (REM) sleep, in dogs. It increases the duration of SWS2, but not SWS1 or REM sleep, in the same model.

• Artikelnummer: CAY29490-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29490-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK