Flufenamic Acid-d4, CAS 1185071-99-1

Formulation: A solid

Formal Name: 2-[[3-(trifluoromethyl)phenyl]amino]-benzoic acid-d4

Purity: ≥99% deuterated forms (d1-d4)

Formula Markup: C14H6D4F3NO2

Formula Weight: 285,3

Shelf life (days): 1460

CAS Number: 1185071-99-1

Notes: Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid (Item No. 21447) by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively).{8427} Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner.{8510} It inhibits calcium influx induced by fMLP (fMLF; Item No. 21495) or A23187 (Item No. 11016) in human polymorphonuclear leukocytes (PMN) with IC50 values of 29 and 14 µM, respectively.{1819} Flufenamic acid also activates various ion channels, including transient receptor potential canonical 6 (TRPC6) and the large-conductance calcium-activated potassium channel (KCa1.1).{60389} It also inhibits various ion channels, including TRPC3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Flufenamic acid (20 mg/kg) reduces increases in intestinal fluid secretion and intestinal barrier disruption in mice infected with the El Tor variant of V. cholerae.{60390}

• Artikelnummer: CAY33272-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33272-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung