Formulation: A crystalline solid
Formal Name: 6α,9-difluoro-11β,21-dihydroxy-16α,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione
Purity: ≥98%
Formula Markup: C24H30F2O6
Formula Weight: 452,5
Shelf life (days): 1460
CAS Number: 67-73-2
Notes: Fluocinolone acetonide is a synthetic fluorinated corticosteroid that acts as a glucocorticoid receptor agonist (IC50 = 2.0 nM in a radioligand binding assay).{39366} It increases transcriptional activity of the glucocorticoid receptor in HeLa cells (EC50 = 0.7 nM). It inhibits VEGF secretion in a dose-dependent manner and decreases TNF-α-induced angiogenesis in a chick chorioallantoic membrane assay.{39365} Formulations containing fluocinolone acetonide have been used for the treatment of various skin, eye, ear, and nose conditions to reduce inflammation.