Fluocinonide, CAS 356-12-7

Formulation: A crystalline solid

Formal Name: 21-(acetyloxy)-6α,9-difluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione

Purity: ≥98%

Formula Markup: C26H32F2O7

Formula Weight: 494,5

Shelf life (days): 1460

CAS Number: 356-12-7

Notes: Fluocinonide is a synthetic fluorinated corticosteroid that binds to the glucocorticoid receptor and has anti-inflammatory properties.{41241,41242} It prevents inflammation and epidermal cell proliferation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014). Fluocinonide inhibits tumor promotion and DNA synthesis in mouse epidermis when applied topically at a dose of 10 µg/0.2 ml. It also acts as an agonist at the smoothened (Smo) receptor with an EC50 value of 1,000 nM in a ligand displacement assay in cells overexpressing the Smo receptor.{41243} Formulations containing fluocinonide are used in the treatment of various skin conditions, including psoriasis and atopic dermatitis.

• Artikelnummer: CAY23803-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23803-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK