Flutamide-d7, CAS 223134-72-3

Formulation: A solid

Formal Name: 2-(methyl-d3)-N-[4-nitro-3-(trifluoromethyl)phenyl]-propanamide-2,3,3,3-d4

Purity: ≥99% deuterated forms (d1-d7)

Formula Markup: C11H4D7F3N2O3

Formula Weight: 283,3

Shelf life (days): 1460

CAS Number: 223134-72-3

Notes: Flutamide-d7 is intended for use as an internal standard for the quantification of flutamide (Item No. 20359) by GC- or LC-MS. Flutamide is an androgen receptor antagonist (Kis = 1.3 and 7.5 µM for the cytosolic rat ventral prostate and anterior pituitary receptors, respectively) and prodrug form of 2-hydroxy flutamide (Item No. 15271).{24727} Flutamide is converted to 2-hydroxy flutamide by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes.{24727} It is cytotoxic to PC3 and LNCaP prostate cancer cells with IC50 values of 98.8 and 81.8 µM, respectively.{54819} Flutamide (50 mg/kg per day) reduces tumor growth in a PC-82 mouse xenograft model.{54820} Formulations containing flutamide have been used in the treatment of prostate cancer.

• Artikelnummer: CAY33541-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33541-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung