FPS-ZM1, CAS 945714-67-0

Formulation: A crystalline solid

Formal Name: 4-chloro-N-cyclohexyl-N-(phenylmethyl)-benzamide

Purity: ≥98%

Formula Markup: C20H22ClNO

Formula Weight: 327,9

Shelf life (days): 1460

CAS Number: 945714-67-0

Notes: FPS-ZM1 is a high-affinity inhibitor of the receptor for advanced glycation end products (RAGE; Ki = 25 nM).{21041} It blocks the binding of amyloid β (Aβ) protein to RAGE and inhibits Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells.{21041} FPS-ZM1 is functional in mice when administered intraperitoneally and penetrates the blood-brain barrier (BBB), inhibiting β-secretase activity, Aβ production, microglia activation, and neuroinflammation.{21041,33327} FPS-ZM1 is used to elucidate the role of RAGE-mediated signaling in diverse physiological processes in vivo, including cancer tumor growth, angiogenesis, and metastasis, as well as BBB damage, edema, and inflammation after intracerebral hemorrhage.{33328,33329}

• Artikelnummer: CAY11909-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 11909-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK