Galantamine (hydrobromide), CAS 1953-04-4

Formulation: A solid

Formal Name: (4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol, monohydrobromide

Purity: ≥98%

Formula Markup: C17H21NO3 • HBr

Formula Weight: 368,3

Shelf life (days): 1460

CAS Number: 1953-04-4

Notes: Galantamine is an alkaloid that has been found in Galanthus and has acetylcholinesterase (AChE) inhibitory and nicotinic acetylcholine receptor (nAChR) potentiating activities.{64099,25283,64100} It selectively inhibits AChE over butyrylcholinesterase (BChE; IC50s = 636 and 8,404 nM, respectively).{25283} Galantamine (0.5 µM) potentiates ACh-induced currents in HEK293 cells expressing human α4β2 subunit-containing nAChRs. In vivo, galantamine (1.3 mg/kg per day) decreases escape latency and path length in the Morris water maze in the APP23 transgenic mouse model of Alzheimer’s disease.{64101} Formulations containing galantamine have been used in the treatment of Alzheimer’s disease.

• Artikelnummer: CAY35247-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35247-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK
• Methode: Reinstoffe