Gemfibrozil-d6, CAS 1184986-45-5

Formulation: A solid

Formal Name: 5-(2,5-dimethylphenoxy)-2,2-di(methyl-d3)-pentanoic acid

Purity: ≥99% deuterated forms (d1-d6)

Formula Markup: C15H16D6O3

Formula Weight: 256,4

Shelf life (days): 1460

CAS Number: 1184986-45-5

Notes: Gemfibrozil-d6 is intended for use as an internal standard for the quantification of gemfibrozil (Item No. 14835) by GC- or LC-MS. Gemfibrozil is a peroxisome proliferator-activated receptor α (PPARα) and PPARγ agonist (EC50s = 193.3 and 147.8 µM, respectively, in transactivation assays).{23621} In vivo, gemfibrozil (50 mg/kg, p.o.) reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia.{54664} Gemfibrozil (100 mg/kg per day) reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif ligand 2 (CCL2) in ApoE-/- mice.{54665} Formulations containing gemfibrozil have been used in the treatment of high cholesterol.

• Artikelnummer: CAY31915-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 31915-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung