GHRP-6 (acetate), CAS 145177-42-0

Formulation: A crystalline solid

Formal Name: L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide, triacetate

Purity: ≥98%

Formula Markup: C46H56N12O6 • 3C2H4O2

Formula Weight: 1053,2

Shelf life (days): 1460

CAS Number: 145177-42-0

Notes: GHRP-6 is a synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R), which is also known as the ghrelin receptor.{49245,3021,49246,49247} It inhibits binding of the GHS-R agonist MK-0677 (ibutamoren; Item No. 18003) to COS-7 cell membranes expressing human GHS-R type Ia (Ki = 1.9 nM) and binding of ghrelin to COS-7 cells expressing human GHS-R (Kd = 260 nM).{3021,49246} GHRP-6 stimulates intracellular calcium mobilization in BHK cells expressing the human receptor (EC50 = 4.5 nM) and inositol phosphate production in COS-7 cells expressing the human receptor (EC50 = 0.83 nM).{49246} It also acts as a negative allosteric modulator of ghrelin (Item Nos. 15072 / 24458) signaling. GHRP-6 (0.03 μg/ml) induces release of GH, but not thyroid-stimulating hormone (TSH), luteinizing hormone (LH), or follicle-stimulating hormone (FSH), in isolated rat pituitary gland.{49245} It increases levels of GH, but not TSH, LH, FSH, or prolactin, in rat blood when administered subcutaneously at a dose of 50 μg. GHRP-6 increases food intake in rats when administered intracerebroventricularly at 0.3, 1, and 3 nmol.{49247}

• Artikelnummer: CAY27262-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27262-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK