Ginkgolide A, CAS 15291-75-5

Formulation: A crystalline solid

Formal Name: (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione

Purity: ≥98%

Formula Markup: C20H24O9

Formula Weight: 408,4

Shelf life (days): 1460

CAS Number: 15291-75-5

Notes: Ginkgolide A is a terpenoid lactone originally isolated from G. biloba leaves with diverse biological activities.{22384} Ginkgolide A inhibits platelet activating factor-dependent aggregation of human platelets (IC50 = 15.8 μg/ml).{43127} It also inhibits GABA-induced currents in Xenopus oocytes expressing human α1β2γ2L GABAA receptors with an IC50 value of 12 μM.{43128} Ginkgolide A (100 μM) reduces the proliferation rate of OVCA429 ovarian cancer cells by 40%.{43129} In vivo, ginkgolide A (1-2 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by 3-fold without altering activity level in mice, indicating anxiolytic-like activity.{43131} Ginkgolide A (10 mg/kg, p.o.) also reduces hexobarbital-induced sleeping time in mice by 44%.{43130} Ginkolide A (30 mg/kg per day) increases activity of the cytochrome P450 (CYP450) isoforms CYP1A2 and CYP2E1 by 1.82- and 1.27-fold, respectively, in rats.{22384}

• Artikelnummer: CAY24970-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24970-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK