Gliquidone, CAS 33342-05-1

Formulation: A crystalline solid

Formal Name: N-[(cyclohexylamino)carbonyl]-4-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isoquinolinyl)ethyl]-benzenesulfonamide

Purity: ≥98%

Formula Markup: C27H33N3O6S

Formula Weight: 527,6

Shelf life (days): 1460

CAS Number: 33342-05-1

Notes: Gliquidone is a second generation sulfonylurea that selectively inhibits ATP-sensitive potassium channel currents (IKATP) in pancreatic β-cells (IC50s = 0.45, 119.1, and 149.7 µM for HIT-T15 cells, cardiomyocytes, and vascular smooth muscle cells, respectively).{49421} It is also a peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 10 μM in a transactivation assay).{49422} Gliquidone (0.2 nmol/g) decreases plasma levels of D-glucose and stimulates insulin release in anesthetized rats.{49423} It decreases blood glucose levels, serum alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) activities, and hepatic lipid peroxidation and increases hepatic glutathione (GSH) levels in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104) when administered at a dose of 10 mg/kg.{49424}

• Artikelnummer: CAY29596-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29596-1
• Green Labware: Nein
• Verpackungseinheit: 1 g
• Mengeneinheit: STK