GLP-2 (rat) (trifluoroacetate salt)

Formulation: A lyophilized powder

Formal Name: L-histidyl-L-alanyl-L-α-aspartylglycyl-L-seryl-L-phenylalanyl-L-seryl-L-α-aspartyl-L-α-glutamyl-L-methionyl-L-asparaginyl-L-threonyl-L-isoleucyl-L-leucyl-L-α-aspartyl-L-asparaginyl-L-leucyl-L-alanyl-L-threonyl-L-arginyl-L-α-aspartyl-L-phenylalanyl-L-isoleucyl-L-asparaginyl-L-tryptophyl-L-leucyl-L-isoleucyl-L-glutaminyl-L-threonyl-L-lysyl-L-isoleucyl-L-threonyl-L-aspartic acid, trifluoroacetate salt

Purity: ≥95%

Formula Markup: C166H256N44O56S • XCF3COOH

Formula Weight: 3796,1

Shelf life (days): 1460

Notes: Glucagon-like peptide 2 (GLP-2) is a gut peptide hormone antagonist of the GLP-2 receptor (GLP-2R; Ki = 60 pM).{41631} It increases cAMP levels in COS cells expressing GLP-2R with an EC50 value of 0.58 nM. GLP-2 is primarily produced by enteroendocrine L cells of the small and large intestine but can also be found in the hypothalamus.{41631,41632} In vivo, GLP-2 (43.75 μg twice per day for 10 days) increases small bowel weight by 50% and increases villus height and crypt cell proliferation in the small intestine in mice.{39479} GLP-2 (10 μg per animal) reduces two-hour food intake in rats by 37% with no reduction in water intake.{41632} Secretion of GLP-2 in rats is stimulated by dietary carbohydrates, glucose, dextrin, and oils rich in polyunsaturated or monounsaturated fatty acids.{30374}

• Artikelnummer: CAY24757-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24757-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK