GLPG0187, CAS 1320346-97-1

Formulation: A crystalline solid

Formal Name: 3-[[2,5-dimethyl-6-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)-1-piperidinyl]-4-pyrimidinyl]amino]-N-[(4-methoxyphenyl)sulfonyl]-L-alanine

Purity: ≥98%

Formula Markup: C29H37N7O5S

Formula Weight: 595,7

Shelf life (days): 1460

CAS Number: 1320346-97-1

Notes: GLPG0187 is a nonpeptide antagonist of αν integrin receptors (IC50s = 1.2-3.7 nM).{38088} It inhibits osteoclastogenesis, bone resorption, and angiogenesis in vitro and in vivo in mice, which are all hallmarks of bone marrow invasion in metastatic prostate cancer. GLPG0187 reduces epithelial-mesenchymal transition (EMT) and migration of PC-3M-Pro4/luc cells in a dose-dependent manner without inhibiting cell growth. GLPG0187 also induces detachment and necrosis of GL-261 and SMA-560 murine glioma cells.{38089}

• Artikelnummer: CAY21792-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21792-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK