GLPG0492, CAS 1215085-92-9

Formulation: A solid

Formal Name: 4-[(4S)-4-(hydroxymethyl)-3-methyl-2,5-dioxo-4-phenyl-1-imidazolidinyl]-2-(trifluoromethyl)-benzonitrile

Purity: ≥98%

Formula Markup: C19H14F3N3O3

Formula Weight: 389,3

Shelf life (days): 1460

CAS Number: 1215085-92-9

Notes: GLPG0492 is a selective androgen receptor modulator (SARM).{53473} It activates the androgen receptor in a transactivation assay (EC50 = 12 nM in HeLa cells expressing the human receptor). GLPG0492 (10 mg/kg per day) increases levator ani muscle weight, a marker of anabolic activity, but has no effect on ventral prostate weight, a marker of androgenic activity, in castrated rats. It increases twitch tension in isolated diaphragm strips, as well as increases the total distance run in a treadmill test and decreases gastrocnemius muscle fibrosis in the exercised-mdx mouse model of muscular dystrophy when administered at a dose of 30 mg/kg.{53474} GLPG0492 also reverses immobilization-induced muscle atrophy in a mouse model of hindlimb immobilization.{53475}

• Artikelnummer: CAY29938
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29938-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK