GLPG1837, CAS 1654725-02-6

Formulation: A crystalline solid

Formal Name: N-[3-(aminocarbonyl)-4,7-dihydro-5,5,7,7-tetramethyl-5H-thieno[2,3-c]pyran-2-yl]-1H-pyrazole-3-carboxamide

Purity: ≥98%

Formula Markup: C16H20N4O3S

Formula Weight: 348,4

Shelf life (days): 1460

CAS Number: 1654725-02-6

Notes: GLPG1837 is a potentiator of cystic fibrosis transmembrane conductance regulator (CFTR).{52061,52059} It increases forskolin-induced opening of wild-type and mutant CFTRs expressing the F508 deletion (F508del) and G551D missense mutations with EC50 values of 88, 3, and 339 nM, respectively, in a reporter assay. GLPG1837 increases forskolin-induced conductivity of patient-derived bronchial epithelial cells expressing both F508del- and G551D-mutant CFTRs (EC50 = 159 nM in a transepithelial clamp circuit (TECC) assay).{52061}

• Artikelnummer: CAY9003143-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9003143-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK