Goserelin (acetate), CAS 145781-92-6

Formulation: A crystalline solid

Formal Name: 2-(aminocarbonyl)hydrazide-6-[O-(1,1-dimethylethyl)-D-serine]-1-9-luteinizing hormone-releasing factor (swine), acetate

Purity: ≥98%

Formula Markup: C59H84N18O14 • XC2H4O2

Formula Weight: 1269,4

Shelf life (days): 1460

CAS Number: 145781-92-6

Notes: Goserelin is a synthetic gonadotropin-releasing hormone (GNRH) agonist that binds to the GNRH receptor (GNRHR; Ki = 1.6 nM, in CHO cells expressing the human receptor).{36464} It binds to mouse pituitary αT3-1 cells and human placenta (Kds = 2 and 580 nM, respectively) and increases intracellular calcium in αT3-1 cells.{36465} Goserelin induces testosterone production in vitro within 4 h in rat Leydig cells (ED50 = 83 nM) but decreases testosterone plasma level in vivo in rats over a period of 2 to 24 weeks.{36466,36467} It inhibits tumor growth in a DU145 human prostate carcinoma mouse xenograft model when administered at a dose of 100 μg per day.{36468} Formulations containing goserelin have been used in the treatment of hormone-dependent breast and prostate cancers, as well as endometriosis and uterine fibroids.

• Artikelnummer: CAY24071-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24071-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK