GR103691, CAS 162408-66-4

Formulation: A solid

Formal Name: 4′-acetyl-N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-[1,1′-biphenyl]-4-carboxamide

Purity: ≥98%

Formula Markup: C30H35N3O3

Formula Weight: 485,6

Shelf life (days): 1460

CAS Number: 162408-66-4

Notes: GR103691 is a dopamine D3 receptor antagonist (Ki = 0.32 nM).{64334} It is selective for dopamine D3 receptors over dopamine D1, D2, and D4 receptors (Kis = 398.11, 39.81, and 81 nM, respectively) and over the serotonin (5-HT) receptor subtype 5-HT1A, α1-adrenergic receptors, and M1 muscarinic receptors (Kis = 3.16, 12.59, and >1,000 nM, respectively).{64334,64335} GR103691 inhibits increases in locomotor activity induced by infusion of the GABAA and GABAC receptor agonist muscimol (Item No. 13667) into the rat ventral tegmental area (VTA; ED50 = 0.3 mg/kg) but not infusion into the substantia nigra zona reticulata (SNr; ED50 = >10 mg/kg).{64334} It increases the time rats spend in the light area of the light-dark exploration test and the open areas of the elevated plus maze without affecting locomotor activity, indicating anxiolytic-like behavior, when injected into the basolateral amygdala (BLA) at a dose of 5 pmol/animal.{64336}

• Artikelnummer: CAY34870-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34870-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK
• Methode: Reinstoffe