GR79236, CAS 124555-18-6

Formulation: A solid

Formal Name: N-[(1S,2S)-2-hydroxycyclopentyl]-adenosine

Purity: ≥98%

Formula Markup: C15H21N5O5

Formula Weight: 351,4

Shelf life (days): 1460

CAS Number: 124555-18-6

Notes: GR79236 is a selective agonist of adenosine A1 receptors (Kis = 3.1 and 1,300 nM for adenosine A1 and A2 receptors, respectively, in rat brain).{47666} GR79236 inhibits cAMP accumulation induced by isoprenaline (isoproterenol; Item No. 15592) in DDT1MF-2 hamster smooth muscle cells (IC50 = 2.6 nM) but only decreases contractility in isolated guinea pig atria with an EC50 value of 1,500 nM. It also inhibits lipolysis induced by norepinephrine (Item No. 16673) in rat adipocytes (EC50 = 0.83 nM).{47667} GR79236 decreases locomotor activity and inhibits DMCM-induced seizures in mice (ED50s = 0.13 and 0.3 mg/kg, respectively).{47666} It also decreases mean blood pressure by 74% in anesthetized rats when administered at a dose of 0.1 mg/kg.

• Artikelnummer: CAY28430-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28430-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK