GS-39783, CAS 39069-52-8

Formulation: A crystalline solid

Formal Name: N4,N6-dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine

Purity: ≥98%

Formula Markup: C15H23N5O2S

Formula Weight: 337,4

Shelf life (days): 1460

CAS Number: 39069-52-8

Notes: GS-39783 is a positive allosteric modulator of GABAB receptors that potentiates GABA-stimulated [35S]GTPγS binding to recombinant human GABAB receptors and rat cortical membranes (EC50s = 2.1 and 3.1 μM, respectively).{53122} It amplifies GABAB receptor-mediated transient calcium signaling in HEK293 cells expressing human receptors (EC50 = 2.4 μM). GS-39783 (25-100 mg/kg) suppresses alcohol self-administration, but has no effect on lever-responding for food, in Indiana alcohol-preferring, Sardinian alcohol-preferring, and Alko Alcohol rats.{53123} It reduces amphetamine- or MK-801-induced hyperactivity in rats and the number of DOI-induced head twitches in mice, indicating antipsychotic-like activity.{53124} GS-39783 also reduces the incidence of sound-induced tonic convulsions in juvenile mice (ED50 = 55.38 mg/kg).{53125}

• Artikelnummer: CAY29482-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29482-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK