GSK3987, CAS 264206-85-1

Formulation: A solid

Formal Name: 3-[(4-methoxyphenyl)amino]-4-phenyl-1-(phenylmethyl)-1H-pyrrole-2,5-dione

Purity: ≥98%

Formula Markup: C24H20N2O3

Formula Weight: 384,4

Shelf life (days): 1460

CAS Number: 264206-85-1

Notes: GSK3987 is a dual agonist of liver X receptor α (LXRα) and LXRβ.{57442} It recruits steroid receptor coactivator 1 (SRC-1) to LXRα and LXRβ in a ligand-sensing assay (LiSA; EC50s = 50 and 40 nM, respectively). GSK3987 is 50-fold selective for LXRα and LXRβ over a panel of nuclear receptors and GSK3β (IC50 = >5,000 nM) but does induce ABCA1 expression in a reporter assay using THP-1 cells (EC50 = 80 nM). It inhibits LPS-induced IL-6 secretion in THP-1 macrophages. GSK3987 increases the expression of the sterol regulatory element binding protein 1c (SREBP-1c) and induces triglyceride accumulation in HepG2 cells in a concentration-dependent manner.

• Artikelnummer: CAY30954
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30954-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK