GSK805, CAS 1426802-50-7

Formulation: A crystalline solid

Formal Name: N-[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)-benzeneacetamide

Purity: ≥98%

Formula Markup: C23H18Cl2F3NO4S

Formula Weight: 532,4

Shelf life (days): 1460

CAS Number: 1426802-50-7

Notes: GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand binding domain without exerting significant effects on DNA binding.{34690} It inhibits the expression of IL-17 (at 0.5 µM) in naïve CD4+ T cells activated under Th17-cell-polarizing conditions and affects the broader RORγt-dependent gene network, inhibiting the development and pathogenic function of Th17 cells. GSK805 significantly reduces the severity of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, when given orally to the hosts at 10 mg/kg daily beginning at the time of disease induction.

• Artikelnummer: CAY9002444-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9002444-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK