Guanfacine-13C,15N3, CAS 1189924-28-4

Formulation: A solid

Formal Name: N-(amino-15N-imino-15N-methyl-13C)-2,6-dichloro-benzeneacetamide-15N

Purity: ≥95%

Formula Markup: C8[13C]H9Cl2[15N]3O

Formula Weight: 250,1

Shelf life (days): 1460

CAS Number: 1189924-28-4

Notes: Guanfacine-13C,15N3 is intended for us as an internal standard for the quantification of guanfacine (Item No. 22907) by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Ki values of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay.{40326} It has EC50 values of 52, 288, and 602 nM for α2A-, α2B-, and α2C-ARs, respectively, for stimulated [35S]GTPγS binding. It also binds to imidazoline receptor 1 (Ki = 19 nM in a radioligand binding assay).{40341} Guanfacine (0.3-5 mg/kg) binds to adrenergic receptors in the central nervous system and lowers blood pressure in hypertensive rats in a dose-dependent manner.{40342} It also improves spatial working memory deficits induced by hypobaric hypoxia in rats.{40340} Formulations containing guanfacine are used in the treatment of high blood pressure and attention deficit hyperactivity disorder (ADHD).

• Artikelnummer: CAY30143
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30143-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung