Guanfacine (hydrochloride), CAS 29110-48-3

Formulation: A crystalline solid

Formal Name: N-(aminoiminomethyl)-2,6-dichloro-benzeneacetamide, monohydrochloride

Purity: ≥98%

Formula Markup: C9H9Cl2N3O • HCl

Formula Weight: 282,6

Shelf life (days): 1460

CAS Number: 29110-48-3

Notes: Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Ki values of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay.{40326} It has EC50 values of 52, 288, and 602 nM for α2A-, α2B-, and α2C-ARs, respectively, for stimulated [35S]GTPγS binding. It also binds to imidazoline receptor 1 (Ki = 19 nM in a radioligand binding assay).{40341} Guanfacine (0.3-5 mg/kg) binds to adrenergic receptors in the central nervous system and lowers blood pressure in hypertensive rats in a dose-dependent manner.{40342} It also improves spatial working memory deficits induced by hypobaric hypoxia in rats.{40340} Formulations containing guanfacine are used in the treatment of high blood pressure and attention deficit hyperactivity disorder (ADHD).

• Artikelnummer: CAY22907-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22907-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK