Halcinonide, CAS 3093-35-4

Formulation: A solid

Formal Name: 21-chloro-9-fluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]-pregn-4-ene-3,20-dione

Purity: ≥98%

Formula Markup: C24H32ClFO5

Formula Weight: 455

Shelf life (days): 1460

CAS Number: 3093-35-4

Notes: Halcinonide is a synthetic glucocorticoid with anti-inflammatory properties.{40483,40484} In a rabbit model of edema, topical application of halcinonide (0.1% w/w) decreases edema by 55% in a reversed passive Arthus skin test (RPA).{40483} Halcinonide (0.1% w/w) inhibits croton oil-induced ear edema by 70.1% and homologous passive cutaneous anaphylaxis (PCA) by 88.0% in rats dosed three hours prior to induction of inflammation.{40484} Application of halcinonide (0.1% w/w) to the abraded surface of cecum in rats inhibits leukocyte adhesion (43.3% incidence versus 100% for controls) and lowers the total number of intraperitoneal leukocytes from 270 million to 121 million 3 days post surgery.{40485} It also acts as an agonist at the smoothened (Smo) receptor with an EC50 value of 1,100 nM.{40486} Formulations containing halcinonide have been used to treat inflammatory and corticosteroid-responsive dermatoses.

• Artikelnummer: CAY23780-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23780-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK