HT-2157, CAS 303149-14-6

Formulation: A solid

Formal Name: 1,3-dihydro-1-phenyl-3-[[3-(trifluoromethyl)phenyl]imino]-2H-indol-2-one

Purity: ≥98%

Formula Markup: C21H13F3N2O

Formula Weight: 366,3

Shelf life (days): 1460

CAS Number: 303149-14-6

Notes: HT-2157 is an antagonist of the galanin-3 receptor (GAL3; Ki = 17 nM).{54910} It is selective for GAL3 over GAL1 and GAL2 (Kis = >10 µM for both). HT-2157 (10 µM) induces apoptosis in various cell types, including HL-60 leukemia and BV-2 murine microglial cells, as well as isolated human peripheral blood mononuclear cells (PBMCs).{54911} It decreases operant alcohol, sucrose, and saccharin self-administration in rats when administered at a dose of 30 mg/kg.{54912} HT-2157 (3 and 10 mg/kg) increases drinking in the Vogel punished drinking task and reduces immobility time in the forced swim test in rats, indicating anxiolytic- and antidepressant-like activities, respectively.{54913}

• Artikelnummer: CAY33848-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33848-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK