Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 3S-[1,3-dihydro-4-[[4-(4-morpholinylmethyl)phenyl]methoxy]-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione
Purity: ≥98%
Formula Markup: C25H27N3O5
Formula Weight: 449.5
CAS Number: 1323403-33-3
Notes: Iberdomide is a modulator of cereblon, a substrate receptor in the CRL4 ubiquitin ligase complex, that has an IC50 value of 60 nM in a competitive TR-FRET assay.{39212} In the same assay, it has a higher affinity for cereblon than the related modulators lenalidomide (Item No. 14643; IC50 = 1,500 nM) and pomalidomide (Item No. 19877; IC50 = 1,200 nM). Iberdomide also has a greater potency for degrading the CRL4 complex substrates Ikaros and Aiolos (EC50s = 1 and 0.5 nM) but has no degradative activity for GSPT1 or CK1α.