Iberdomide, CAS 1323403-33-3

Formulation: A crystalline solid

Formal Name: 3S-[1,3-dihydro-4-[[4-(4-morpholinylmethyl)phenyl]methoxy]-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione

Purity: ≥98%

Formula Markup: C25H27N3O5

Formula Weight: 449,5

Shelf life (days): 1460

CAS Number: 1323403-33-3

Notes: Iberdomide is a modulator of cereblon, a substrate receptor in the CRL4 ubiquitin ligase complex, that has an IC50 value of 60 nM in a competitive TR-FRET assay.{39212} In the same assay, it has a higher affinity for cereblon than the related modulators lenalidomide (Item No. 14643; IC50 = 1,500 nM) and pomalidomide (Item No. 19877; IC50 = 1,200 nM). Iberdomide also has a greater potency for degrading the CRL4 complex substrates Ikaros and Aiolos (EC50s = 1 and 0.5 nM) but has no degradative activity for GSPT1 or CK1α.

• Artikelnummer: CAY22615-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22615-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK