ICA 069673, CAS 582323-16-8

Formulation: A crystalline solid

Formal Name: N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-benzamide

Purity: ≥98%

Formula Markup: C11H6ClF2N3O

Formula Weight: 269,6

Shelf life (days): 1460

CAS Number: 582323-16-8

Notes: ICA 069673 is a heteromeric Kv7 channel activator.{39323,39324} It is selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively) and also activates Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels in a dose-dependent manner.{39324} ICA 069673 has no activity against hERG, Nav1.5, and Kv7.1 cardiac ion channels (IC50s = >30 μM).{39323} Oral administration of ICA 069673 increases latency to first tonic-clonic seizure in the rat maximal electroshock and pentylentetrazol-induced seizure models (ED50s = 1.5 and <1 mg/kg, respectively).{39323} Formulations containing ICA 069673 are under clinical investigation for the treatment of epilepsy.

• Artikelnummer: CAY22995-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22995-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK