ICA 121431, CAS 313254-51-2

Formulation: A crystalline solid

Formal Name: α-phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-benzeneacetamide

Purity: ≥98%

Formula Markup: C23H19N3O3S2

Formula Weight: 449,5

Shelf life (days): 1460

CAS Number: 313254-51-2

Notes: ICA 121431 is a voltage-gated sodium channel (Nav) blocker that selectively blocks Nav1.1 and Nav1.3 over Nav1.4, and Nav1.5-1.8 channels (IC50s = 10,000 nM, respectively).{36656} It induces a concentration-dependent hyperpolarizing shift in voltage dependence of inactivation of Nav1.3 channels at a concentration 1 μM but has no effect on resting channels. Substitution of the Nav1.3 domain IV voltage-sensor domain (VSD4) with the Nav1.5 VSD4 reduces ICA 121431 potency by approximately 500-fold.

• Artikelnummer: CAY24669-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24669-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK