Indacaterol-d3, CAS 2699828-16-3

Formulation: A solid

Formal Name: 5-((1R)-2-((5-ethyl-6-(ethyl-2,2,2-d3)-2,3-dihydro-1H-inden-2-yl)amino)-1-hydroxyethyl)-8-hydroxy 2(1H)-quinolinone

Purity: ≥99% deuterated forms (d1-d3)

Formula Markup: C24H25D3N2O3

Formula Weight: 395,5

Shelf life (days): 1460

CAS Number: 2699828-16-3

Notes: Indacaterol-d3 is intended for use as an internal standard for the quantification of indacaterol (Item No. 20070) by GC- or LC-MS. Indacaterol is a long-acting and selective β2-adrenergic receptor (β2-AR) agonist (EC50 = 8.71 nM for increasing intracellular cAMP levels in vitro).{32131} It is selective for β2-ARs over β1- and β3-ARs (Kis = 43.6, 616.6, and 3,311.3 nM, respectively). Indacaterol inhibits bronchoconstriction induced by serotonin (5-HT; Item No. 14332) in conscious guinea pigs with a maximal effect of 85% when administered intratracheally at a dose of 6.7 µg/kg. It also inhibits bronchoconstriction induced by methacholine (Item No. 23092) in rhesus monkeys with a maximal effect of 75% when administered via nebulization at a dose of 12.5 mg/kg. Formulations containing indacaterol have been used alone, and in combination with glycopyrrolate, in the treatment of chronic obstructive pulmonary disease.

• Artikelnummer: CAY28886
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28886-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung