Irbesartan-d4, CAS 1216883-23-6

Formulation: A solid

Formal Name: 3-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl-2,3,5,6-d4)methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one

Purity: ≥99% deuterated forms (d1-d4)

Formula Markup: C25H24D4N6O

Formula Weight: 432,6

Shelf life (days): 1460

CAS Number: 1216883-23-6

Notes: Irbesartan-d4 is intended for use as an internal standard for the quantification of irbesartan (Item No. 11952) by GC- or LC-MS. Irbesartan is an antagonist of the angiotensin II type 1 (AT1) receptor (Ki = 1.3 nM).{21001} It is an insurmountable antagonist of AT1, as its antagonism cannot be overcome by increasing concentrations of angiotensin II.{21393} Irbesartan (3, 10, and 30 mg/kg) reduces blood pressure in stroke-prone spontaneously hypertensive rats and increases survival of SPSH rats fed a high-salt low-protein diet.{43281} It also reduces plaque formation, collagen content, as well as the increased expression of the AT1 receptor, PDGF-b, MCP-1, and VCAM-1 in a model of diabetes-induced atherosclerosis using apolipoprotein E (ApoE) knockout mice with diabetes induced by streptozotocin (STZ; Item No. 13104).{43280} Formulations containing irbesartan have been used, alone and in combination with diuretics, in the treatment of hypertension.

• Artikelnummer: CAY25509-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25509-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung